PHILADELPHIA—Pre-diabetes is associated with an increased risk of overactive bladder (OAB) in women, new data presented at the International Continence Society’s 2018 annual meeting.

Even modestly elevated fasting plasma glucose (FPG) and HbA1c are independently associated with an increased likelihood of OAB in women. Among women, an FPG of 110 to 125 mg/dL was associated with significant 46% increased odds of OAB compared with an FPG less than 100 mg/dL (reference), Yoshitaka Aoki, MD, PhD, and colleagues from the University of Fukui in Fukui, Japan, reported. An HbA1c of 5.5% to 5.9% was associated with significant 31% increased odds of OAB compared with an HbA1c less than 5.5% (reference). The investigators found no significant association between FPG or HbA1c and OAB in men.

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The study included 5771 individuals (3473 women and 2298 men) aged 40 to 69 years who participated in a multi-phasic health screening. Participants had a median age of 65 years. Overall, 409 women (11.8%) and 189 men (8.2%) reported urgency. All patients underwent a detailed health evaluation and all were asked to answer a standardized questionnaire for OAB screening.

“To our knowledge, this is the first study in a population-based sample of men and women to assess the potential role of pre-diabetes in the development of OAB,” the authors wrote in a study abstract. “These results indicate that bladder storage function may be affected even in pre-diabetes in women.”


Aoki Y, Okada M, Ito H, et al. A relationship between pre-diabetes and overactive bladder-analysis of a health-screening program in men and women. Data presented at the International Continence Society’s 2018 annual meeting in Philadelphia, August 28–31. Abstract 275.