Higher body mass index (BMI) is independently associated with improved survival of patients with metastatic and castration-resistant prostate cancer (PCa), according to study findings presented at the 2017 Genitourinary Cancers Symposium in Orlando, Florida.
In a study of 79 patients with metastatic or castration-resistant PCa, Zachary A. Glaser and colleagues at Vanderbilt University Medical Center in Nashville, Tennessee, found that each 1-unit increment in BMI was associated with a significant 16% lower risk of death in multivariate analysis.
The study cohort had a mean age of 64 years, and 69% of patients were Caucasian. The median BMI was 28.5 kg/m2. Of the 79 patients, 25 (31.6%) were obese (BMI of 30 kg/m2 or higher) and 18 (22.7%) had diabetes mellitus.
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The estimated 5-year overall survival rate was significantly lower among patients with diabetes mellitus than without (77.1% vs. 92.7%). The estimated 5-year OS rate was 93.9% for obese patients compared with 84.1% for non-obese patients, a non-significant difference.
According to senior investigator Kelvin Moses, MD, PhD, FACS, these findings suggest that increased reserve may be protective in patients with advanced prostate cancer.
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Reference
1. Glaser Z, Avulova S, Stocks B, et al. The association of BMI and DM with survival among patients with metastatic and/or castration-resistant prostate cancer. Data presented in poster format at the 2017 Genitourinary Cancers Symposium in Orlando, Florida. Poster Session A Board #H9. Abstract 207.
