Reduced kidney function is associated with increased risks for hospitalization for heart failure and cardiovascular (CV) and all-cause mortality among older adults, according to data presented at the European Renal Association (ERA) 59th Congress held in Paris, France, and virtually.
In a prospective population-based study of 1466 community-dwelling individuals aged 70 years or older (mean 79 years) and without heart failure at baseline, Antonios Douros, MD, of McGill University in Montreal, Canada, and colleagues found that individuals with reduced kidney function (estimated glomerular filtration rate [eGFR] less than 60 mL/min/1.73 m2) had a higher crude incidence rate of hospitalization for heart failure compared with those who had retained kidney function (eGFR of 60 mL/min/1.73 m2 or higher): 2.7 vs 1.1 events per 100 persons per year. After adjusting for potential confounders, reduced kidney function was significantly associated with a nearly 1.5-fold increased risk for hospitalization for heart failure.
Compared with individuals who had retained kidney function, those with reduced kidney function had a higher crude incidence rate for CV death (2.7 vs 0.9 events per 100 persons per year) and all-cause mortality (6.3 vs 2.8 events per 100 persons per year), Dr Douros’ team reported. In adjusted analyses, the group with decreased kidney function had an approximately 1.5- and 1.3-fold increased risk for CV death and all-cause mortality, respectively.
“Our population-based study showed that decreased kidney function is associated with increased risks of cardiovascular morbidity and cardiovascular and all-cause mortality among older adults, corroborating findings in younger populations,” the investigators concluded in a study abstract.
Douros A, Schneider A, Ebert N, et al. Kidney function and the risk of heart failure among older adults: A prospective population-based cohort study. Presented at: ERA 59th Congress, May 19-22, 2022. Abstract MO195.