Preeclampsia increases the risk of post-pregnancy chronic kidney disease (CKD), according to study findings presented at the 55th European Renal Association-European Dialysis and Transplant Association congress in Copenhagen, Denmark. The risk is especially high in the first 5 years after pregnancy.

The findings, reported by Jonas H. Kristensen, MD, of Statens Seruminstitut in Copenhagen and colleagues, is from a study of 1,072,330 women in Denmark with pregnancies lasting 20 weeks or more. During a mean follow-up of 18.6 years per woman, CKD developed in 3901 women. Compared with women who did not have a history of preeclampsia who had delivered in the same gestational age, women with a history of early preterm (less than 34 weeks), late preterm (34–36 weeks), and term (37 weeks or more) preeclampsia had a significant 3.9-, 2.8- and 2.3-fold increased risk of post-pregnancy CKD, respectively.

The associations between preeclampsia and post-pregnancy glomerular diseases was particularly striking, the investigators noted. For example, early preterm preeclampsia was associated with a significant 5-fold increased risk of glomerular diseases years after delivery.

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Associations with unspecific chronic kidney impairment and hypertensive kidney disease also were strong, according to the researchers. For example, preterm preeclampsia was associated with a significant 2.9- and 4.2-fold increased risk of these problems, respectively.

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The associations between any preeclampsia and unspecific chronic kidney impairment and glomerular diseases were much more pronounced within 5 years of pregnancy. The risk of unspecific chronic kidney impairment and glomerular diseases among women with any preeclampsia was increased by 5.5- and 4.4 fold within 5 years of pregnancy and by 2.1- and 1.5-fold 5 or more years after pregnancy.


Kristensen JH, Basit S, Wohlfahrt J, et al. Preeclampsia and the risk of renal disease. Presented at the 55th ERA-EDTA congress in Copenhagen, Denmark, May 24–27. Abstract FO061.