AMSTERDAM—Individuals with a parental history of cardiovascular disease (CVD) are more likely to develop kidney problems than those without history of parental CVD, researchers reported at the 51st Congress of the European Renal Association-European Dialysis and Transplant Association.

Juan J. Carrero, MD, Karolinska Institute in Huddinge, Sweden, and colleagues conducted a cross-sectional study of parental CVD history and renal function in a large group of community-based adult men and women enrolled in the Aerobics Center Longitudinal Study (ACLS).  The ACLS is an ongoing prospective, observational study of men and women aged 20 years or older who underwent comprehensive medical examinations including serum creatinine examinations at a clinic in Dallas from April 1994 to February 2004. The analysis included 3,339 individuals with and 9,902 without parental CVD.

“Current guidelines recommend that individuals with a positive parental history of CVD or CKD should be considered at risk of developing CVD or CKD, respectively,” said Dr. Carrero, associate professor of renal medicine. “However, despite similar etiologies, it remains unknown if a broader relationship between these diseases exists across generations.”

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Information on premature parental CVD history, defined as a parental CVD history before the age of 50 years, was obtained using a questionnaire. Estimated glomerular filtration rate (eGFR) was assessed by serum creatinine, and CKD was defined as an eGFR below 60mL/min/1.73m2.
Results showed that participants with parental CVD had significantly lower eGFR compared with those without parental CVD (69.4 vs. 74.8 mL/min/1.73m2).

In adjusted analyses, CVD was independently associated with a 68% increased odds of having CKD.

The eGFR declined by 0.15 mL/min/1.73m2 annually among those with parental CVD, which was significantly more rapid that the 0.10 mL/min/1.73m2 annual decline among individuals without parental CVD.

The findings support “previously unrecognized cross-generational links: between both CVD and CKD and should be incorporated into community screening programs,” Dr. Carrero said.