Male sex increases the risk for in-hospital COVID-19 mortality among patients with nondialysis-dependent chronic kidney disease (NDD-CKD), investigators reported at the 58th European Renal Association-European Dialysis and Transplant Association 2021 virtual congress.

Among patients with NDD-CKD hospitalized with COVID-19, male sex was independently associated with a 1.9-fold increased risk for 28-day in-hospital mortality in adjusted analyses, Armando Coca, MD, of the Hospital Clinico Universitario in Valladolid, Spain, reported. Male sex was not associated with increased in-hospital mortality among patients without CKD.

Dr Coca and his colleagues conducted a multicenter observational cohort study that included 136 adult patients with NDD-CKD and 136 age- and sex-matched controls hospitalized due to COVID-19. The 28-day in-hospital mortality rate was 40.4% in the CKD group compared with 24.3% in the control group.

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Compared with the control group, the CKD group had a significantly higher proportion of patients with hypertension (89.7% vs 70.2%) and diabetes (40.4% vs 22.8%). In both groups, age was an independent predictor of 28-day in-hospital mortality.

None of the variables examined in the study predicted intensive care unit admission.

The investigators defined NDD-CKD as a sustained estimated glomerular filtration rate of less than 60 but greater than 15 mL/min/1.73 m2 within the 6 months prior to COVID-19 hospitalization. In all patients with COVID-19, polymerase chain reaction assays and/or serologic testing confirmed infection with SARS-CoV-2, the novel coronavirus that causes COVID-19.


Coca A, Burballa  C, Centellas FJ, et al. Male sex is associated with in-hospital death in non-dialysis CKD patients with COVID-19. Presented at: ERA-EDTA 2021 virtual congress held June 5-8. Abstract MO206.