Kidney donor gender has no significant impact on long-term recipient and graft survival, according to study data presented at the 56th European Renal Association-European Dialysis and Transplant Association Congress in Budapest, Hungary.

A team led by Adnan Sharif, MBChB, MD, a transplant nephrologist at University Hospitals Birmingham in the United Kingdom, analyzed data available for 25,140 kidney transplants. Of these, 13,414 kidneys (53.4%) were from male donors and 15,690 (62.4%) of recipients were male.

After up to 10 years of follow-up, the sexes of the donors and recipients made no significant difference in patient or graft survival. Male and female recipients of female kidneys, however, had significant 11% and 19% decreased risks of delayed graft function or primary non-function, Dr Sharif’s team reported in a poster presentation.

Results also showed that recipients of female donor kidneys had significantly higher creatinine levels at 1 year post-transplant, regardless of recipient gender. Male recipients of female donor kidneys had 1-year creatinine levels that were, on average, 6.3% higher than those of male recipients of male donor kidneys. Similarly, female recipients of female donor kidneys had 1-year creatinine levels that were, on average, 4.1% higher than the levels among female recipients of male donor kidneys.

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“While further work is warranted to confirm our results in other contemporary population cohorts, this study is reassuring for patients and professionals alike with regards to equivalent patient and graft survival for kidney transplant recipients, regardless of donor sex,” the authors concluded.

Reference

Morgan G, Goolam-Mahomen Z, Hodson J, et al. Donor sex and recipient outcomes after kidney transplantation: A population cohort analysis from the United Kingdom. Presented at the 56th European Renal Association-European Dialysis and Transplant Association Congress in Budapest, Hungary, June 13 to 16. Abstract FP780.

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