Among patients with nondialysis-dependent chronic kidney disease (CKD), the risk for premature death is lower in those with obese rather than normal body mass index (BMI), investigators reported at the European Renal Association (ERA) 59th Congress held in Paris, France, and virtually.
Among 2420 patients in the Salford Kidney Study with a median follow-up duration of 44.3 months, the risk for all-cause mortality was a significant 12% lower for patients with a BMI of 30 kg/m2 or more (obese) vs 18.5-24.9 kg/m2 (normal), Saif Al-Chalabi, MBChB, MD, of Northern Care Alliance NHS Foundation Trust in Salford, UK, and colleagues reported. Investigators obtained the same result in a propensity-score-matched analysis comparing 414 obese and 414 normal-weight individuals.
BMI did not influence the risks for CKD progression or end-stage kidney disease (ESKD) in either analysis. The median estimated glomerular filtration rate (eGFR) was 29.3 mL/min/1.73 m2 and did not differ between BMI groups.
Hypertension (84.0% vs 91.7% vs 94.2%) and diabetes (18.8% vs 31.0% vs 46.8%) became more prevalent as BMI category increased from normal to overweight to obese, respectively. Previous research has suggested that BMI fluctuations and metabolic disturbances predict poor outcomes in CKD.
Al-Chalabi S, Nawaz S, Lodge M, Sinha S, Kalra PA, Chinnadurai R. Impact of body mass index on mortality and end-stage kidney disease in patients with non-dialysis dependent chronic kidney disease. Presented at: ERA 59th Congress; May 19-22, 2022, Paris, France, and virtual. Abstract MO412.