Women with a history of gestational diabetes are at elevated risk for chronic kidney disease (CKD) and end-stage kidney disease (ESKD) later in life if they develop type 2 diabetes mellitus, according to study data presented at the virtual 58th congress of the European Renal Association-European Dialysis and Transplant Association.
The finding is from a retrospective cohort study of 1,121,633 women in Sweden, of whom 15,595 (1.4%) were diagnosed with gestational diabetes. Women who experienced gestational diabetes, compared with those who did not, had a significantly 1.8- and 4.5-fold increased risk for CKD and ESKD, respectively, in adjusted analyses, according to investigator Karolina Kublickiene, MD, PhD, of Karolinska Institutet in Stockholm, Sweden. Women who had gestational diabetes had a significant 8.8-, 2.5-, and 1.9-fold increased risk for diabetic CKD, hypertensive CKD, and glomerular CKD, respectively.
These associations were largely explained by the progression of gestational diabetes to type 2 diabetes, according to investigators. Women whose gestational diabetes progressed to type 2 diabetes had a significant 21.7-fold increased risk for CKD and 112.4-fold increased risk for ESKD. Women whose gestational diabetes did not progress to type 2 diabetes were not at significantly elevated risk for CKD or ESKD compared with women who have uncomplicated pregnancies.
Barrett P, McCarthy F, Evans M, et al. Gestational diabetes and the long-term risk of maternal kidney disease: a Swedish national cohort study. Presented at: 58th ERA-EDTA virtual congress held June 5-8, 2021. Abstract MO489.