Chronic kidney disease (CKD) is more common among patients with cancer compared with the general population, and its prevalence varies with the type of cancer, investigators reported at the 58th European Renal Association-European Dialysis and Transplant Association virtual congress.
The findings are from a study of 5831 Romanian patients with cancer who had a median age of 64 years. Investigators used serum creatinine measurements levels to calculate estimated glomerular filtration rate (eGFR) at baseline and during 2 years of follow-up period. They defined CKD as an eGFR less than 60 mL/min/1.73 m2 persistent for more than 3 months.
At baseline, approximately 11.9% of patients had CKD, Adalbert Schiller, MD, of the Victor Babeş University of Medicine and Pharmacy of Timisoara in Timisoara, Romania, reported in an oral presentation. The prevalence of CKD rose to 14.5% after the first year of follow-up, which was significantly higher than the general population of Romania (8.8% in 2008). After 2 years, the prevalence was 15%. The average decrease in eGFR was 4.7 mL/min/1.73 m2 per year.
The prevalence of CKD was highest among patients with kidney cancer (48.7%), followed by those with urinary bladder cancer (34.1%), liver cancer and multiple myeloma (both 20.0%), and pancreatic cancer (19.6%). The prevalence was lowest in patients with uterine cancer (5.7%), brain cancer (7.1%), and testicular cancer (8.8%).
Ciorcan M, Chisavu L, Gadalean F, et al. Chronic kidney disease in neoplasia patients, the analysis of a large cancer database. Presented at: 58th ERA-EDTA 2021 virtual congress. Abstract MO525.