Acute kidney injury is associated with a lower risk of subsequent kidney stone formation, according to data presented at the European Renal Association-European Dialysis and Transplant Association 2020 virtual congress.

Hicham Cheikh Hassan, MB BCh, of Wollongong Hospital in New South Wales, Australia, and colleagues studied 180,927 hospitalized adult patients, of whom 12,338 (6.8%) were diagnosed with AKI and 4495 (2.5%) with kidney stones. Patients with AKI were more likely to be older (75 vs 50 years) and have more comorbidities such as diabetes (21.5% vs 9.4%), hypertension (31.8% vs 12.7%), coronary artery disease (14.6% vs 7%), and peripheral vascular disease (5.4% vs 1.8%), the investigators reported.

The proportion of patients with kidney stones was significantly lower in those with a history of AKI than in those who never had AKI (1.1% vs 2.5%). A history of AKI was significantly associated with a 58% decreased risk of kidney stones compared without such a history.

When the investigators compared the 12,338 AKI patients with a propensity score matched cohort of 12,338 patients with no AKI, they found that AKI was significantly associated with a 43% decreased risk of kidney stones.


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“Our findings suggest that patients with AKI appear to be at significantly lower risk of developing subsequent kidney stone formation when compared to patients with no previous AKI episodes,” Dr Hassan’s team concluded in a poster presentation.

The investigators explained that AKI may result in long-term renal damage and fibrosis. A potential effect is impairment in urine concentration that would limit kidney stone formation, they noted. No prior study has examined this potential association.

Reference

Hassan HC, Lonergan M, Mullan J, et al. Acute kidney injury as a risk factor for kidney stones: a propensity matched analysis. Presented at the European Renal Association_European Dialysis and Transplant Association 2020 virtual congress. Abstract P0561.