Incidental prostate cancer found at radical cystectomy for bladder cancer is typically indolent, investigators reported at the 38th Congress of the European Association of Urology (EAU23) in Milan, Italy.
Chi Hang Yee, MBBS, and colleagues from S.H. Ho Urology Centre, The Chinese University of Hong Kong, reviewed data from 193 men at their institution without evidence of prostate cancer who underwent cystoprostatectomy from 1998 to 2017. Of the cohort, 31 patients (16.1%) had incidental prostate cancer, Dr Yee reported. All prostate cancers were pT2a stage with Grade Group 1.
Patients with vs without prostate cancer had a significantly higher mean age: 71.1 vs 67.5 years, according to Dr Yee. They also had numerically higher pre-operative PSA (4.47 vs 2.84 ng/mL), but the difference was not significant.
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On multivariate analysis, older age was significantly associated with 11% increased odds of incidental prostate cancer at radical cystectomy. Among the variables studied—age, use of neoadjuvant therapy, preoperative PSA, margin status of the bladder tumor, and bladder cancer T stage and grade, only older age independently predicted incidental prostate cancer.
None of the 31 patients with incidental prostate cancer experienced recurrence over a mean 10.4 years of follow up, Dr Yee reported. He cautioned that Asian case series typically report fewer clinically significant prostate cancers compared with series from other parts of the world.
Reference
Yee CH, Ho FW, Ng TCK, et al. Risk of concomitant prostate cancer in bladder cancer patients going for radical cystectomy. Presented at: EAU23 Congress, Milan, Italy, March 10-13. Abstract A0286.
