Circadian syndrome may increase the risk for kidney stones, investigators suggested at the 38th Annual Congress of the European Association of Urology (EAU23) in Milan, Italy.

In a cross-sectional analysis of the 2007-2018 National Health and Nutrition Examination Survey (NHANES), 1559 of 4603 overweight adults (33.9%) had circadian syndrome. Kidney stone prevalence was significantly higher among individuals with vs without circadian syndrome: 14.5% vs 8.5%, Yunfei Xiao, MD, MS, of West China Hospital, Sichuan University in Chengdu, China, reported on behalf of his team. Similarly, circadian syndrome was more prevalent among adults who formed kidney stones compared with those who did not: 40.2% vs 26.9%, he reported. In a fully adjusted model, circadian syndrome was significantly associated with 1.4-fold increased odds of stones.

Certain groups had especially high risk, according to Xiao. Among adults aged 35-49 years and women, those with circadian syndrome had 2.7- and 1.6-fold increased odds of kidney stones, respectively. Mexican Americans and adults of other races with circadian syndrome had 3.8- and 4.9-fold increased odds of stones, respectively.

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Xiao suggested that avoiding circadian syndrome by adopting a healthy lifestyle may prevent or reduce the risk of developing kidney stones.

Circadian syndrome encompasses and possibly explains metabolic syndrome, according to emerging research. It links circadian rhythm disruption to poor lifestyle behaviors. Adults with circadian syndrome meet at least 4 of the following criteria: sleep less than 6 hours per night, depression symptoms (CES-D score of 10 or higher), large waist circumference, elevated triglycerides, low HDL cholesterol, elevated blood pressure, and elevated fasting glucose.


Cui J, Xiao Y, Yin S, Wang J, Bai Y, Wang J. The association between circadian syndrome and the prevalence of kidney stones in overweight Americans aged ≥20 years old: A cross-sectional analysis of NHANES 2007-2018. Presented at: EAU23 Congress, Milan, Italy, March 10-13. Abstract A0381.