Individuals with greater concentrations of high-density lipoprotein (HDL) may be less likely to form kidney stones, according to study results presented at the 38th Annual Congress of the European Association of Urology (EAU23) in Milan, Italy.

Jianwei Cui, MD, and colleagues from West China Hospital of Sichuan University in Chengdu, China, studied 30,969 individuals aged 20 years or older who participated in the National Health and Nutrition Examination Survey from 2007 to 2018. Compared with individuals in the lowest quartile of HDL levels (2.88-18.54 mg/dL), those in the highest quartile (28.44-105.12 mg/dL) had significant 13% reduced odds of kidney stones in a fully adjusted model.

The model adjusted for sex, age, race, education, marital status, smoking status, alcohol use, comorbidities, physical activity, and other variables.

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The authors noted that dysregulation of lipid metabolism is associated with kidney stones, but evidence related to the relationship between HDL and kidney stones has been limited.

In an earlier study of Chinese individuals published in Urologia Internationalis, investigators found that low HDL levels were significantly associated with 7.6-fold increased odds of kidney stones. Using fasting plasma lipid profiles, they compared 540 kidney stone cases with a control group of 656 kidney stone-free individuals.


Cui J, Xiao Y, Wang J, Bai Y, Yin S, Wang J. Association between high-density lipoprotein and kidney stones in Americans aged ≥20 years old: A cross-sectional analysis of NHANES 2007-2018. Presented at: EAU2023, Milan, Italy, March 10-13, 2023. Abstract A0380.

Ding Q, Ouyang J, Fan B, et al. Association between dyslipidemia and nephrolithiasis risk in a Chinese population. Urol Int. 2019;103(2):156-165. doi:10.1159/000496208