Moderate to severe chronic kidney disease (CKD) may increase the risk for severe nocturia in men, new findings presented at the European Association of Urology 2020 virtual congress suggest.

Among 530 Japanese men (mean age 72 years) with lower urinary tract symptoms, 30%, 23%, and 47% had 0 to 1, 2, or 3 or more nightly voids. CKD stage 1 to 2, 3A, 3B, and 4 to 5 were observed in 70%, 21%, 5%, and 3%, respectively. Severe nocturia (3 or more nightly voids) was found in 44% and 47% of men with CKD stage 1 to 2 and 3A but 76% and 73% of men with CKD stage 3B and 4 to 5, respectively.

Men with stage 3B or higher CKD were significantly more likely to experience severe nocturia than those with lower stage CKD: 75% vs 45%, Noriyuki  Iida, MD, of Komagome Hospital, Tokyo, Japan, and colleagues reported. In multivariable analyses, CKD stage 3B or higher was significantly associated with triple the risk for severe nocturia and age older than 72 years with double the risk.

The study is the first to show that higher CKD stage is associated with severe nocturia in men, the investigators stated.


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In the 2013-2014 National Health and Nutrition Examination Survey, investigators likewise examined nocturia in 9813 individuals. Nocturia (defined as waking up nightly to urinate) was more prevalent in individuals with CKD—39.4% in CKD stages 3 and 4 and 38.7% in CKD stages 1 and 2—compared with 24.3% in those with no CKD.

“The higher burden of sleep problems among adults with CKD, especially with stages 3 and 4, highlights the importance for early detection and management of these symptoms in the primary and specialty care settings,” according to the Centers for Disease Control and Prevention.

References

Iida N, Ito M, Nakanishi Y, et al. Impact of severe chronic kidney disease on severe nocturia in men. Presented at: EAU20 Virtual Congress; July 17 to 19, 2020. Poster 137.

Sleep Problems Are More Common in Adults With Chronic Kidney Disease. Centers for Disease Control and Prevention. https://nccd.cdc.gov/ckd/AreYouAware.aspx?emailDate=August_2020 Accessed August 4, 2020.