Elevated urinary sodium levels can have a significant impact on hypercalciuria and recurrence of stone disease, researchers concluded in a poster presented at the Canadian Urological Association annual meeting in Vancouver.
Marie S. Dion, MD, and collaborators at Western University in London, Ontario, Canada, reviewed prospective data from 914 kidney stone patients with initial 24-hour urine analyses seen at a metabolic stone clinic, of whom 189 (20.7%) had elevated urinary sodium levels. Of these, 81 (42.9%) also had hypercalciuria, a rate twice that of hypercalciuria in the overall population (21.9%).
On a second 24-hour urine analysis, 60 patients were able to achieve normal urinary sodium levels. In these patients, hypercalciuria resolved in 85%. In multivariate analysis of 1,229 24-hour urine samples, elevated urinary sodium was associated with a significant 2.5 increased odds of hypercalciuria.
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Stone patients should be counseled regarding the importance of dietary salt restriction, with a high rate of resolution of hypercalciuria expected in patients able to decrease salt intake, Dr Dion’s team concluded.
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