The prevalence of major comorbidities among men and women with nocturnal polyuria (NP) differs according to NP subtype, according to findings from a population-based US study presented at the AUA2021 Virtual Experience.

“Nocturnal polyuria is an important healthcare issue affecting a significant proportion of the population and occurring more frequently with increasing age,” Christopher R. Chapple, BSc, MD, of the University of Sheffield in the UK told Renal & Urology News. “It is important to recognize the implications of this condition, not only in terms of quality of life but also morbidity and longevity. Recognition of other conditions that may contribute to nocturnal polyuria is essential.”

For the Epidemiology of Nocturnal Polyuria (EpiNP) study (NCT 04125186), 10,190 individuals aged 30 years and older responded to a comprehensive online survey. Of these, 1766 had 2 or more voids nightly and completed a 3-day bladder diary. Using the data, the investigators stratified patients into NP subgroups: Pure NP (no underlying cause), NP with symptoms suggestive of overactive bladder (NPOAB) or bladder outlet obstruction (NPBOO; men only), NP due to other comorbidities (diabetes, hypertension, heart disease, sleep apnea), and no NP (did not meet NUP90 or NPI33 criteria).

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Pure NP was associated with younger age compared with the other subtypes: Mean patient age was approximately 50 years vs 56-62 years. Idiopathic NP was less prevalent among men than women (NUP90: 3.2% vs 5.5% and NPI33: 5.5% vs 13.0%, respectively). Compared with the other NP groups, patients with pure NP had smaller mean waist circumference (men: 39.4 cm; women: 36.7 cm) and the least obesity (men: 29.4%; women: 34.3%).

Among men, NPBOO represented the largest subgroup (NPI33: 19.1%; NUP90: 15.7%), while among women, NPOAB was the largest (NPI33: 29.6%; NUP90: 15.4%).

Most of the pure NP group had no other urologic conditions (94.1% of men and 88.6% of women), unlike the other NP groups where up to a third of patients had other urologic problems, Dr Chapple reported. Men had more urologic conditions, such as kidney stones, compared with women.

The other NP subgroups had higher prevalence of most medical comorbidities. In the NP due to other comorbidities subgroup, men had higher rates than women of hypertension (83.7% vs 78.8%), diabetes (34.9% vs 31.8%), heart disease (23.3% vs 4.5%), and sleep apnea (30.2% vs 12.1%).

Anxiety, depression, and arthritis were fairly common across groups, except for the younger aged patients in the pure NP group.

“The findings from this study highlight the importance of considering the multifactorial causes of NP,” Dr Chapple stated. “They emphasize the need to consider the prevalence and associated comorbid factors that contribute to NP in both sexes, as well as the clinical importance of this condition and its impact on health-related quality of life.”

Disclosure: This research was supported by Ferring. Please see the original reference for a full list of disclosures.


Chapple CR, Rosenberg MT, Bacci ED, Brooks AB, Andersson FL, Ruud Bosch JLH. Comorbid conditions associated with nocturnal polyuria: Results from the Epidemiology of Nocturnal Polyuria (EpiNP) study. Presented at: AUA2021 Virtual Experience held September 10-13, 2021. Poster MP08-19.