|The following article features coverage from the American Urological Association (AUA) 2019 meeting. Click here to read more of Renal & Urology News’ conference coverage.|
CHICAGO—Positive surgical margins (PSMs) following partial nephrectomy for cT1b renal cell carcinoma (RCC) are associated with worse outcomes, according to study finding presented at the 2019 American Urological Association annual meeting.
“Post-operative surveillance and management reflective of a higher risk profile may be warranted for these individuals,” investigators concluded in a study abstract.
In a study involving 2737 patients, Ahmed Eldefrawy, MD, of the University of California San Diego School of Medicine in La Jolla, and colleagues found that PSMs were significantly associated with reduced 5-year recurrence-free and overall survival compared with negative surgical margins (68.7% vs 91.5% and 60% vs 81.4%), respectively, among patients with cT1b RCC, but not those with cT1a RCC.
Of the 2737 patients, 1842 had cT1a and 774 had cT1b RCC. Patients had a median follow-up of 44.4 months. A total of 113 patients had PSMs. On multivariable analysis, age, black race, PSM, high tumor grade, and cT1b staging were independently associated with disease recurrence and increased mortality.
Read more of Renal & Urology News’ coverage of the AUA 2019 meeting by visiting the conference page.
Eldefrawy A, Bradshaw A, Uzzo R, et al. Negative impact of positive margins in partial nephrectomy in stage 1 renal cell carcinoma: A multicenter analysis. Presented at the 2019 American Urological Association annual meeting held May 3-6 in Chicago. Abstract PD46-03.