Previous radiation may increase mortality risk for patients with bladder cancer, according to a poster presentation at SUO 2020, the virtual annual meeting hosted by the Society of Urologic Oncology.

Using the Surveillance, Epidemiology, and End Results (SEER) database, investigators identified 15,034 patients with bladder cancer as a second malignancy. Patients who received prior ionizing radiation (with the bladder in field) had 4% and 12% increased all-cause and bladder cancer-specific mortality at 5 years, respectively, compared with patients who did not receive radiation, Syed M. Alam, MD, of the University of Kansas Health System in Kansas City reported.

The investigators examined stage-specific survival in a subanalysis of 5041 patients. Among patients with nonmuscle-invasive bladder cancer, prior radiation increased 5-year all-cause and bladder cancer-specific risks by 1.5- and 2.2-fold, respectively, among patients with carcinoma in situ (CIS), 1.5- and 1.3-fold among those with stage Ta disease, and 1.1- and 1.3-fold, respectively, among those with stage T1 cancer.

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The data also trended toward worse bladder cancer-specific survival for patients with muscle-invasive bladder cancer who received prior radiation.

“Urologists caring for bladder cancer patients with a history of radiation should be aware of the increased risk and the potential for different behavior of these tumors,” Dr Alam stated.


Alam SM, Chollet-Hinton L, Thompson J, Holzbeierlein JM. Effect of prior radiation on survival in bladder cancer: a population analysis. Presented at: SUO 2020, December 3-5, 2020. Poster 50.