Men with a history of priapism are at increased risk for venous thrombotic/embolic events, according to research presented at the 2022 American Urological Association annual meeting in New Orleans, Louisiana.
Evan Mulloy, MD, of Stanford University in Palo Alto, California, and colleagues compared 10,428 men with priapism with a matched control group of 20,854 men with erectile dysfunction (ED), 9571 with Peyronie’s disease (PD), and 9363 with premature ejaculation (PE). The study population had a median age of 51.2 years.
The investigators compared the priapism group with the ED, PD, and PE groups with respect to their risk for thromboembolic and cardiovascular outcomes. Compared with the men who had ED, the men with priapism (including those with sickle cell disease, a known risk factor for priapism) had a significant 24% increased risk for acute embolism and thrombosis of deep veins in the lower extremities and a 30% increased risk for other venous embolism and thrombosis, the investigators reported in a poster presentation. They also had a significant 12% increased risk for cerebrovascular disease. When men with sickle cell disease were excluded from the priapism group, these men had a significant 21%, 28%, and 10% higher risk for these conditions, respectively.
Similarly, compared with the men who had PD, the priapism group had a significant 51% increased risk for acute embolism and thrombosis of deep veins in the lower extremities and 54% increased risk for other venous embolism and thrombosis. They also had a significant 65% increased risk for pulmonary embolism and infarction.
The men with priapism vs those with PE had a significant 68% increased risk for pulmonary embolism and infarction and 48% increased risk for other venous embolism and thrombosis. They also had a significant 20% increased risk for cerebrovascular disease.
“Men with priapism may be at increased risk for pulmonary and venous thrombotic/embolic events in the subsequent years following their priapism diagnosis,” the authors concluded.
Mulloy E, Li S, Eisenberg M. Demographics and incidental diagnoses of men with priapism. Presented at AUA2022, May 13-16, 2022, New Orleans, Louisiana. Poster MP21-16.