Men with erectile dysfunction (ED) are at increased risk for major adverse cardiovascular events (MACE), especially those who live in rural areas, according to study findings presented at the 2022 American Urological Association annual meeting in New Orleans, Louisiana.
The study included 428,241 men, of whom 49,959 had ED (32,138 from urban areas and 17,821 from rural areas) and 378,282 did not (233,073 and 145,209 from urban and rural areas, respectively).
Overall, MACE occurred in 8.9% of men with ED compared with 4.6% of those without ED. The proportions of men who experienced MACE were 8.2% and 10.2% among men with ED from urban and rural areas, respectively, and 4.2% and 5.2%, respectively, for men without ED from urban and rural areas, respectively.
Compared with men from urban areas who did not have ED, men with ED who lived in rural areas and those with ED from urban areas had a significant 54% and 26% higher risk for MACE, respectively, in weighted analyses, investigator Uday Mann, MD, of the University of Manitoba in Winnipeg, Canada, reported.
Among men with ED, those from rural areas had a significant 22% higher risk for MACE compared with those from an urban setting. Among men without ED, men from rural areas had a significant 14% increased risk for MACE compared with those from urban areas.
The median time to a MACE was 2721, 2620, 2520, and 2438 days in the ED urban, ED rural, no ED rural, and no ED urban groups, respectively.
The investigators adjusted for age, socioeconomic status, diabetes, hypertension, dyslipidemia, renal disease, and index year.
“It is imperative for health care professionals who manage patients with ED to discuss the risk of future cardiovascular disease and identify comorbid conditions to mitigate risk,” Dr Mann concluded.
The investigators considered men to have ED if they had at least 2 ED prescriptions (including oral, intraurethral, and/or injection therapies) filled within 1 year. They defined MACE as myocardial infarction, coronary revascularization procedures, ischemic stroke, or hospitalization for heart failure.
Mann U, Brar R, Patel P. Erectile dysfunction is an independent risk factor for major adverse cardiovascular events. Presented at AUA 2022, May 13-16, 2022, New Orleans, Louisiana. Abstract PD49-05.