ORLANDO—Results of an animal study suggest that penile traction therapy has a better effect on curvature correction in Peyronie’s disease (PD), whereas a vacuum erectile device has a better effect on erectile function preservation, researchers reported at the American Urological Association 2014 annual meeting.

Haocheng Lin, MD, PhD, and Run Wang, MD, of the University of Texas M.D. Anderson Cancer Center in Houston, induced Peyronie’s plaque in 15 adult male rats using an established Peyronie’s disease animal model. At week 4, Drs. Lin and Wang measured penile curvature and divided the rats into three groups of 5 each. One group had penile traction therapy (PTT), another group had a vacuum erectile device (VED) applied to their penis, and the third group served as controls.

Both the PTT and VED groups had reduced penile curvature at 8 weeks compared with measurements at week 4 and control group at week 8. Penile curvature was reduced by 65% in the PTT group and by 33% in the VED group. The VED group, however, had a higher intracavernosal pressure/mean arterial pressure ratio compared with the two other groups at week 8 (0.70 vs. 0.47 in the PTT group and 0.42 in the control arm).

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“Combination therapy might be a good option for PD,” the authors concluded.