SAN DIEGO—Data presented at the American Urological Association annual meeting show that collagenase injections can decrease penile curvature in men with Peyronie’s disease compared with placebo, regardless of baseline severity of penile curvature.
The data, reported by Larry Lipshultz, MD, of the Baylor College of Medicine in Houston, and colleagues, are from the randomized, placebo-controlled IMPRESS I and II phase 3 studies of collagenase, which enrolled 303 and 309 men with Peyronie’s disease, respectively. Researchers examined treatment outcomes from baseline to 52 weeks.
Men with baseline curvature of 30º to 60º responded as well to treatment as subjects with a curvature of 61º to 90º. In IMPRESS I, these men experienced a 39% and 31% improvement from baseline, respectively; in IMPRESS II, they experienced a 28% and 38% improvement. PD symptom bother score improved by 3.6 and 1.9 points and 2.2 and 3.0 points. All of these improvements were significantly better than those associated with placebo.
For the studies, CCH patients received a maximum of four treatment cycles, each separated by a six-week period. Patients received up to eight injections of 0.58 mg of collagenase, two injections per cycle separated by about 24 to 72 hours.