ATLANTA—Diabetes has no influence on intravesical botulinum toxin type A (BoNTA) injection in overactive bladder (OAB) patients, researchers reported at the American Urological Association 2012 annual meeting.

In addition, OAB patients with diabetes mellitus (DM) have a significantly higher incidence of large post-voiding residuals and general weakness than non-diabetic patients.

Taiwanese researchers Chung-Cheng Wang, MD, and Hann-Chorng Kuo, MD, identified 217 patients who had received BoNTA injections, 48 of whom had DM. Videourodynamics were performed at baseline and repeated at three months after intravesical BoNTA injection.

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Upon injection, diabetic OAB patients had a 60.4% rate of post-voiding residuals whereas non-diabetic OAB patients  had a rate of 33.3% as well as a higher incidence of general weakness (10.4% vs. 0%). No major complications were observed in either group. Baseline urodynamic parameters could not account for adverse effects in diabetic patients.

“BoNTA injection was a safe and effective treatment for patients with OAB and diabetes,” the researchers concluded.