ATLANTA—Women are more likely than men to have advanced bladder cancer disease found at the time of radical cystectomy and to die from the cancer, according to researchers at the American Urological Association 2012 annual meeting.
In a retrospective study using the Surveillance, Epidemiology and End Results (SEER) database, researchers identified 12,843 patients diagnosed with bladder cancer.
Although men had a higher prevalence of bladder cancer (75%), women were more likely to be older at diagnosis (69 vs. 67 years), be of black race (8% vs. 4%), and to have non-organ-confined disease at diagnosis (39% vs. 35%), the researchers, led by Marco Bianchi, MD, of Vita-Salute San Raffaele University in Milan, Italy, found.
Cancer-specific mortality (CSM) was significant higher in women than men (33% vs. 23%), which translated into a 22% increased risk of CSM in women. Among patients with non-organ-confined disease, women and men had five-year CSM rates of 22% and 17%, respectively, which translated into a significant 24% increased risk of CSM for women compared with men. Among patients with non-organ-confined disease, the five-year CSM rates for women and men were 46% and 40%, which translated into a significant 22% increased risk of CMS for women.
In addition, the study showed that women were 22% more likely than men to die from cancer even after adjusting for other-cause mortality.