ATLANTA—Lower renal function is associated with an increased independent risk for renal and urothelial cancer, according to data presented at the American Urological Association 2012 annual meeting.

William Lowrance, MD, of the Huntsman Cancer Institute, University of Utah in Salt Lake City, and colleagues examined data from about 1.2 million patients aged 40 years and older with no prior dialysis treatment, renal transplant, or known cancer who received care in the Kaiser Permanente Northern California health system. The researchers identified new cancers using a comprehensive regional cancer registry.

The investigators identified 76,809 new cancer diagnoses during 6.0 million person-years of follow-up. The risk of renal cancer increased with decreasing estimated glomerular filtration rate (eGFR). Compared with subjects who had an eGFR above 60 mL/min/1.73 m2, those with an eGFR of 45-59 and 30-44 had a 35% and 65% increased risk of renal cancer, after adjusting for potential confounding factors. The risk was increased twofold among subjects with an eGFR below 30. Investigators observed similar associations between eGFR and urothelial cancer, but no association between eGFR and prostate, colorectal, lung, or breast cancer.

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