WASHINGTON, D.C.—Statin use by hyperlipidemic patients may decrease the risk of urinary stone formation, according to study findings presented at the American Urological Association 2011 annual meeting.
The study of 57,326 hyperlipidemic patients by James Masterson, MD, of the Naval Medical Center in San Diego, and collaborators demonstrated that statin use was associated with a significant 50% decreased risk of urinary stones compared with non-users, even after adjusting for age, gender, obesity, diabetes, hypertension, and cardiovascular disease. Statin use decreased the risk significantly by about 41% in men and about 64% in women.
The study population consisted of active duty members of the armed services and their dependents as well as armed services retirees. Of the 57,326 patients, 1,998 had a history of nephrolithiasis. Among the stone formers, 1,030 used statins (3.2%) and 968 (3.9%) did not.
In addition, the study showed that obesity, hypertension, and diabetes mellitus were associated with a significant 53%, 75%, and 39% increased risk of stone formation, in adjusted analyses.