Certain urinalysis findings prior to kidney donors’ death may predict an increased risk of death or graft loss in recipients, according to data presented at the 2019 American Transplant Congress in Boston.
In a retrospective study of 199 adult patients who underwent kidney transplantation, Amanda J. Vinson, MD, and colleagues from Dalhousie University in Halifax, Nova Scotia, found that the presence of leukocyte esterase and greater than 10 epithelial cells per high powered field in pre-terminal (less than 72 hours before organ retrieval) urine specimens were significantly associated with a 4.2-fold and 3.3-fold increased risk of a composite outcome of death or graft loss. In addition, each 1% increase in panel-reactive antibody was significantly associated with a 1% increased risk of the composite outcome.
Of the 199 patients, 52 (26.1%) experienced graft loss or death (26 graft failures and 26 deaths). The median length of follow-up was 6.2 years.
Vinson A, Keough-Ryan T, West K, Tennankore K. The implications of donor proteinuria in deceased donor kidney transplantation. Presented at the 2019 American Transplant Congress in Boston, June 1-5. Abstract B159.