SEATTLE—Small donor size has an adverse impact on allograft function following living kidney donor transplantation, researchers reported at the 2013 American Transplant Congress.

Hasan Khamash, MD, and colleagues at Mayo Clinic Arizona in Phoenix retrospectively studied 579 pairs of living kidney donors and recipients who had their estimated glomerular filtration rate (GFR) ascertained at one year post-transplant. Values below 40 mL/min/1.73 m2 were considered low. Investigators found an eGFR below 40 in 19% of patients who received kidneys from donors with a body surface area (BSA) less than 1.7 m2 compared with only 8% of those who received kidneys from donors with a BSA above 1.7 m2.

After adjusting for multiple variables, a donor BSA less than 1.7 m2 was associated with a significant 2.4 times increased likelihood of having a low eGFR at one year post-transplant.

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Other factors that independently increased the likelihood of low eGFR included older donor age and lower donor eGFR.