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Among older kidney transplant recipients, those with higher Charlson Comorbidity Index (CCI) scores appear to have worse graft survival and mortality, researchers reported at the 2017 American Transplant Congress in Chicago.
Argiris Asderakis, MD, and colleagues at the University Hospital of Wales in Cardiff, UK, examined outcomes over 3 years for 62 patients older than 60 years who had received transplanted kidneys from donors with cardiac death (DCD).
A CCI score was calculated for each patient at the time of surgery, which reflected the sum of 17 comorbidities weighted for disease severity and mortality risk. CCI scores ranged from 2 to 10 for the entire group.
Patients with CCI score below 5 had higher 1- and 3-year survival rates than those with a score of 5 or more (94% vs 90% and 90% vs 76%, respectively.
Based on estimated glomerular filtration rate, graft function between the groups appeared to diverge after 18 months. Graft survival at 3 years was 97% vs 90%, respectively. The investigators found no significant correlation between CCI and graft function at 1 or 2 years.
Asderakis A, Contractor U, Khalid U, Donato P, Szabo L. Charlson Comorbidity Index (CCI) as Prognostic Indicator of Outcomes in Older Patients Undergoing Renal Transplantation. Am J Transplant [abstract] 2017:17 (suppl 3). Presented at the 2017 American Transplant Congress in Chicago, April 29–May 3, 2017. Abstract A107.