Hypertensive patients without diabetes may be at lower risk of new-onset diabetes if they take at least 1 blood pressure (BP)-lowering medication at bedtime, according to data presented at the American Society of Hypertension annual meeting in New York.

In a prospective, randomized trial of 2,012 hypertensive patients without diabetes mellitus, Ramón C. Hermida, PhD, Campus Universitario, Vigo, Spain, and colleagues found that subjects who took 1 or more BP medications at bedtime had a significant 57% decreased risk of new-onset diabetes than those who took all of their BP medications upon awakening. They also had improved ambulatory BP control.

Diabetes developed in 171 (8.5%) of the 2,012 patients during a median follow-up of 5.6 years.

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The study population had a median age of 52.7 years and consisted of 976 men and 1,036 women.