The prevalence of chronic kidney disease (CKD) has increased among U.S. adults aged 80 years or older, according to research published in the Journal of the American Medical Association.

C. Barrett Bowling, M.D., M.S.P.H., of the Veterans Affairs Medical Center in Atlanta, and colleagues analyzed data from the National Health and Nutrition Examination Surveys for 1988 to 1994 and 1999 to 2010 to assess the prevalence of CKD in adults aged 80 years or older.

The researchers found that the prevalence of an estimated glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m² in those 80 years or older increased from 40.5 percent in 1988-1994 to 49.9 percent in 1999-2004 and 51.2 percent in 2005-2010. For the same time periods, an estimated GFR of less than 45 mL/min/1.73 m² increased from 14.3 to 18.6 and 21.7 percent, respectively.

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“Along with studies suggesting increased risk for adverse outcomes at lower estimated GFR levels, the current analysis suggests efforts to address CKD among the oldest old may be necessary,” the authors write.

One author disclosed financial ties to Amgen; another author disclosed receiving royalties from UpToDate.