Gout

Gout Increases Chronic Kidney Disease Risk

Gout Increases Chronic Kidney Disease Risk

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In an observational UK study, chronic kidney disease stage 3 or higher was 78% more likely to develop in patients with vs without gout during a median follow-up of 6 years.

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol use is not associated with renal function decline among those with newly diagnosed gout.

High Gout Burden Found Among Solid Organ Transplant Recipients

High Gout Burden Found Among Solid Organ Transplant Recipients

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Study reveals an 11% prevalence of active gout among solid organ transplant recipients overall and a 13% prevalence among kidney transplant recipients.

Febuxostat Increases CV Event Risk Only in Established CV Disease

Febuxostat Increases CV Event Risk Only in Established CV Disease

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Spanish study found no significant difference between febuxostat and allopurinol with respect to risk of new cardiovascular events among gout patients without prior cardiovascular disease.

Obstructive Sleep Apnea May Increase Gout Risk

Obstructive Sleep Apnea May Increase Gout Risk

People with obstructive sleep apnea continued to be at higher risk of developing gout after the first year of obstructive sleep apnea diagnosis.

Clinical Gout-Related Benefits Not Seen With Lesinurad Combo Tx

Clinical Gout-Related Benefits Not Seen With Lesinurad Combo Tx

Although a combination of lesinurad 200 mg and xanthine oxidase inhibitor therapy was effective and well-tolerated among patients with gout, clinical gout-related benefits were not improved.

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound examination may be used to detect crystal deposition in the renal medulla in patients with tophaceous gout.

Knee, Metatarsophalangeal Joint Exam May Improve Gout Diagnosis

Knee, Metatarsophalangeal Joint Exam May Improve Gout Diagnosis

Researchers evaluated the distribution of ultrasound features of lower-limb joints and the risk factors of tophus in patients with gout.

Gout Attack Risk Lowered With Interleukin-1ß Blockade

Gout Attack Risk Lowered With Interleukin-1ß Blockade

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Inhibition of IL-1ß with canakinumab significantly decreased gout attack risk at all baseline serum uric acid (SUA) levels and without changing SUA levels.

Gout Patients Have Lower Prevalence of Colorectal Cancer

Gout Patients Have Lower Prevalence of Colorectal Cancer

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The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.

Gout Associated With Increased Hearing Loss Risk in the Elderly

Gout Associated With Increased Hearing Loss Risk in the Elderly

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Hearing impairment is 44% more likely to develop in Medicare patients with vs without gout, a study of Medicare claims data shows.

Gout Increases Atrial Fibrillation Risk in the Elderly

Gout Increases Atrial Fibrillation Risk in the Elderly

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A study of Medicare patients found that atrial fibrillation was nearly twice as likely to develop in those with vs without gout.

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Serum urate level is a strong predictor of incident gout, but only about half of patients with hyperuricemia develop clinically evident gout.

Emergency Department Gout Visits Rise Dramatically

Emergency Department Gout Visits Rise Dramatically

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US study documents a 27% increase in visits to emergency departments for a primary diagnosis of acute gout from 2006 to 2014.

Mortality Risks Higher With Febuxostat vs Allopurinol

Mortality Risks Higher With Febuxostat vs Allopurinol

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All-cause and cardiovascular mortality risks were 22% and 34% higher among febuxostat-treated patients vs allopurinol recipients.

FDA Issues Safety Alert for Gout Medication

FDA Issues Safety Alert for Gout Medication

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Febuxostat may increase the risk for heart-related death.

Erectile Dysfunction Risk Higher in Gout Patients

Erectile Dysfunction Risk Higher in Gout Patients

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The risk for developing erectile dysfunction is 15% higher among men with than without gout.

Gout Patient Hospitalizations Soar

Gout Patient Hospitalizations Soar

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All-cause hospitalizations in the US increased 410% from 1993 to 2014 among gout sufferers compared with 4.8% in the general population.

Gout Risk Is Lower Among Healthier Eaters

Gout Risk Is Lower Among Healthier Eaters

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A DASH-style diet is associated with a reduced risk of gout, whereas a Western diet is associated with a higher risk.

Most US Gout Sufferers Not Taking Urate-Lowering Drugs

Most US Gout Sufferers Not Taking Urate-Lowering Drugs

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Gout is uncontrolled in the majority of individuals with the condition, data show.

Women With Gout at Greater Risk for Hip Fracture

Women With Gout at Greater Risk for Hip Fracture

The multivariable-adjusted relative risk of hip fracture was 1.38 in women with history of gout.

Black Gout Sufferers Have Worse HRQoL

Black Gout Sufferers Have Worse HRQoL

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Blacks had significantly higher median baseline serum urate levels compared to whites.

ACP Releases New Gout Guidelines

ACP Releases New Gout Guidelines

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The guidelines recommend treatment strategies and state that evidence is insufficient to support therapy to lower uric acid to target levels.

Lesinurad Improves Uric Acid Lowering in Gout Sufferers

Lesinurad Improves Uric Acid Lowering in Gout Sufferers

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Using the drug together with allopurinol helps more patients achieve target uric acid levels of less than 6 mg/dL.

Gout Found to Increase Type 2 Diabetes Risk

Gout Found to Increase Type 2 Diabetes Risk

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The effect of gout on type 2 diabetes risk was more profound in women than men.

Venous Thromboembolism Linked to High Uric Acid

Venous Thromboembolism Linked to High Uric Acid

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Highest vs lowest uric acid levels associated with a 2-fold increased risk of VTE.

Higher Allopurinol Dose Protects Elderly From Renal Failure

Higher Allopurinol Dose Protects Elderly From Renal Failure

A higher allopurinol dose was protective against renal failure in elderly allopurinol recipients.

Most Gout Inadequately Controlled

Most Gout Inadequately Controlled

Patients with inadequately controlled gout experience lower quality of life and report worse functioning.

Researchers: View Gout as a Warning Sign

Researchers: View Gout as a Warning Sign

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Gout is associated with an elevated risk of comorbid conditions, especially hypertension and alcohol abuse.

Gout Increases Risk of Erectile Dysfunction

Gout Increases Risk of Erectile Dysfunction

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Gout is associated with an elevated likelihood of both organic and psychogenic ED.

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