Inhibition of IL-1ß with canakinumab significantly decreased gout attack risk at all baseline serum uric acid (SUA) levels and without changing SUA levels.
The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.
Hearing impairment is 44% more likely to develop in Medicare patients with vs without gout, a study of Medicare claims data shows.
A study of Medicare patients found that atrial fibrillation was nearly twice as likely to develop in those with vs without gout.
Serum urate level is a strong predictor of incident gout, but only about half of patients with hyperuricemia develop clinically evident gout.
US study documents a 27% increase in visits to emergency departments for a primary diagnosis of acute gout from 2006 to 2014.
All-cause and cardiovascular mortality risks were 22% and 34% higher among febuxostat-treated patients vs allopurinol recipients.
Febuxostat may increase the risk for heart-related death.
The risk for developing erectile dysfunction is 15% higher among men with than without gout.
All-cause hospitalizations in the US increased 410% from 1993 to 2014 among gout sufferers compared with 4.8% in the general population.
A DASH-style diet is associated with a reduced risk of gout, whereas a Western diet is associated with a higher risk.
Gout is uncontrolled in the majority of individuals with the condition, data show.
The multivariable-adjusted relative risk of hip fracture was 1.38 in women with history of gout.
Blacks had significantly higher median baseline serum urate levels compared to whites.
The guidelines recommend treatment strategies and state that evidence is insufficient to support therapy to lower uric acid to target levels.
Using the drug together with allopurinol helps more patients achieve target uric acid levels of less than 6 mg/dL.
The effect of gout on type 2 diabetes risk was more profound in women than men.
Highest vs lowest uric acid levels associated with a 2-fold increased risk of VTE.
A higher allopurinol dose was protective against renal failure in elderly allopurinol recipients.
Patients with inadequately controlled gout experience lower quality of life and report worse functioning.
Gout is associated with an elevated risk of comorbid conditions, especially hypertension and alcohol abuse.
Gout is associated with an elevated likelihood of both organic and psychogenic ED.
Gout increased the risk of erectile dysfunction in men by 21%.
Guidelines currently don't recognize gout as a risk factor for CKD and nephrolithiasis.
The incidence of gout among CKD patients was 6.82 per 1,000 persons per year compared to 2.43 for those without the disease.
Although 87% of patients met the criteria for urate-lowering treatment within 5 years, only 30% were prescribed the recommended treatment.
Analysis found that cigarette smoking was associated with a 24% overall reduction in gout risk.
Women with this form of arthritis are more susceptible to diabetes, researchers say.
Each 5-unit increment in BMI is associated with a 55% increased relative risk of gout.
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