HIV-Infected Living Kidney Donors Have Low ESRD Risk
HIV-positive individuals with well-controlled disease and no comorbidities have a low risk of ESRD following living kidney donation.
HIV-positive individuals with well-controlled disease and no comorbidities have a low risk of end-stage renal disease (ESRD) following living kidney donation, researchers concluded in a paper published online ahead of print in the American Journal of Transplantation.
Abimereki D. Muzaale, MD, MPH, of Johns Hopkins University in Baltimore, and colleagues compared with the incidence of end-stage renal disease (ESRD) among 41,968 HIV-positive patients followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative individuals followed for a median of 14 years.
For 40-year-old HIV-positive individuals with health characteristics similar to those of age-matched kidney donors, CD4+ count of 500 cells/μL or higher, and viral load less than 400 copies/mL, the 9-year cumulative incidence of ESRD was higher than that of their HIV-negative counterparts, but still low: 3.0 versus 1.3 per 10,000 among white men, 2.5 versus 1.1 per 10,000 among white women, 15.8 versus 4.4 per 10,000 among black men, and 13.2 versus 3.6 per 10,000 among black women, the researchers reported.