ESRD Uncommon Among Type 1 Diabetes Patients

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The researchers found that 4.6% of participants developed ESRD and 20.6% died during 30 years of follow-up.
The researchers found that 4.6% of participants developed ESRD and 20.6% died during 30 years of follow-up.

HealthDay News — Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up, according to a study published online in Diabetes Care.

Vibeke Gagnum, from Oslo University Hospital in Norway, and colleagues examined the long-term mortality, causes of death, and ESRD in a population-based cohort study involving 719 patients with type 1 diabetes diagnosed at ages 15 to 27 years. Information on causes of death and whether ESRD was present was obtained from linkage to national registries.

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The researchers found that 4.6% of participants developed ESRD and 20.6% died during 30 years of follow-up. Cumulative mortality was 6.0% at 10 years since diagnosis, 12.2% at 20 years, and 18.4% at 30 years. The standardized mortality ratio was 4.4. There was a mean of 23.6 years from diabetes diagnosis to ESRD. Causes of death included chronic complications (32.2%), acute complications (20.5%), violent death (19.9%), or any other cause (27.4%). In 15% of cases, death was related to alcohol.

"The cumulative incidence of ESRD was low in this cohort with type 1 diabetes followed for 30 years," the authors write. "Mortality was 4.4 times that of the general population, and more than 50% of all deaths were caused by acute or chronic complications."

Reference

  1. Ranjan A, Schmidt S, Damm-Frydenberg C, et al. Low Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Cross-Over Study. Diabetes Care. October 2016. http://dx.doi.org/10.2337/dc16-1472
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