Edema:
Indications for: ZAROXOLYN
Edema.
Adult Dosage:
Individualize. 5–20mg once daily.
Children Dosage:
Not established.
ZAROXOLYN Contraindications:
Anuria. Hepatic coma or precoma.
ZAROXOLYN Warnings/Precautions:
Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.
ZAROXOLYN Classification:
Diuretic (quinazoline).
ZAROXOLYN Interactions:
Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.
Adverse Reactions:
Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).
How Supplied:
Tabs—100, 1000
Hypertension:
Indications for: ZAROXOLYN
Hypertension.
Adult Dosage:
Individualize. 2.5–5mg once daily.
Children Dosage:
Not established.
ZAROXOLYN Contraindications:
Anuria. Hepatic coma or precoma.
ZAROXOLYN Warnings/Precautions:
Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.
ZAROXOLYN Classification:
Diuretic (quinazoline).
ZAROXOLYN Interactions:
Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.
Adverse Reactions:
Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).
How Supplied:
Tabs—100, 1000
