XYNTHA SOLOFUSE Rx

Individualize and titrate. Give by IV infusion over several minutes. One IU of factor VIII per kg raises the plasma factor VIII activity by about 2 IU/dL. Dose (IU) = Body Weight (kg) × Desired % Factor VIII Increase × 0.5. Bleeding (Minor): obtain 20–40% FVIII increase every 12–24hrs for ≥1 day depending on severity; (Moderate): obtain 30–60% FVIII increase every 12–24hrs for 3–4 days or until hemostasis achieved; (Major): obtain 60–100% FVIII increase every 8–24hrs until resolved. Peri-op (Minor): obtain 30–60% FVIII increase every 12–24hrs for 3–4 days or until hemostasis achieved (for tooth extraction: a single dose plus oral antifibrinolytic therapy within 1hr may be sufficient); (Major): obtain 60–100% FVIII increase every 8–24hrs until resolved or adequate healing achieved. Routine prophylaxis (<12yrs): initially 25 IU/kg every other day (more frequent or higher doses may be required); (≥12yrs): initially 30 IU/kg 3 times weekly. Adjust dose based on response.