Anxiety/OCD:
Indications for: XANAX
Anxiety. Panic disorder.
Adult Dosage:
Adjust at intervals of at least 3–4 days. ≥18yrs: Anxiety: initially 0.25–0.5mg 3 times daily; max 4mg daily in divided doses. Elderly or hepatic impairment: initially 0.25mg 2–3 times daily. Panic disorder: initially 0.5mg 3 times daily; usual range: 5–6mg daily in divided doses; max 10mg/day.
Children Dosage:
<18yrs: not established.
XANAX Contraindications:
Concomitant strong CYP3A inhibitors (eg, itraconazole, ketoconazole), except ritonavir.
Boxed Warning:
Risks from concomitant use with opioids. Abuse, misuse, and addiction. Dependence and withdrawal reactions.
XANAX Warnings/Precautions:
Increased risk of drug-related mortality from concomitant use with opioids. Suicidal ideation (monitor). Depression. Psychosis. Mania. Renal, cardiovascular, hepatic, or respiratory impairment; monitor. Discontinue if respiratory depression, hypoventilation, or apnea occurs. Monitor periodic CBCs, urinalysis, blood chemistry. Reevaluate periodically. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Write ℞ for smallest practical amount. Avoid abrupt cessation. Change dose gradually. Drug or alcohol abusers. Elderly. Neonatal sedation and withdrawal syndrome; monitor neonates exposed during pregnancy or labor. Pregnancy (esp. late stage). Nursing mothers: not recommended.
See Also:
XANAX Classification:
Benzodiazepine.
XANAX Interactions:
See Contraindications; other azole antifungals: not recommended. Increased sedation, respiratory depression, coma, and death with concomitant opioids; reserve use in those for whom alternative treatment options are inadequate; if needed, limit dosages/durations to minimum and monitor. Additive CNS depressant effects with alcohol or other CNS depressants (eg, other benzodiazepines, psychotropics, anticonvulsants, antihistamines); consider dose reductions. Potentiated by moderate or weak CYP3A inhibitors (eg, nefazodone, fluvoxamine, cimetidine, erythromycin); avoid or reduce alprazolam dose. Antagonized by CYP3A inducers (eg, carbamazepine, phenytoin); caution. Concomitant ritonavir; adjust alprazolam dose (see full labeling). Potentiates digoxin; monitor serum levels. May increase levels of imipramine, desipramine.
Adverse Reactions:
CNS depression (eg, drowsiness, sedation, memory impairment, dysarthria, coordination abnormal, ataxia), hypotension, fatigue, lethargy, dyspnea, dry mouth, constipation, tremors, changes in libido, sexual dysfunction, paradoxical excitement, withdrawal reactions.
Drug Elimination:
Renal. Half-life: ~11.2 hours
Generic Drug Availability:
YES
How Supplied:
XR—60; Tabs 0.25mg, 0.5mg, 1mg—100, 500, 1000; 2mg—100, 500
