Urine acidification/alkalinization:

Indications for: UROCIT-K

Renal tubular acidosis with calcium stones. Hypocitraturic calcium oxalate nephrolithiasis. Uric acid lithiasis.

Adult Dosage:

Take within 30mins of meals or bedtime snack. Adjust based on urinary citrate levels and/or pH. Urinary citrate <150mg/day: 30mEq twice daily or 20mEq 3 times daily. Urinary citrate >150mEq/day: 15mEq twice daily or 10mEq 3 times daily. Max 100mEq/day.

Children Dosage:

Not established.

UROCIT-K Contraindications:

See full labeling. Hyperkalemia or predisposing conditions. Delayed gastric emptying, esophageal compression, intestinal obstruction or stricture. Peptic ulcer disease. UTI. Renal insufficiency (GFR <0.7mL/kg/min).

UROCIT-K Warnings/Precautions:

Restrict salt intake and encourage high fluid intake. Discontinue if severe vomiting, GI pain or bleeding occurs and follow-up. Monitor 24 hour urinary citrate, urinary pH, serum electrolytes, CBC, ECG, at least every 4 months; discontinue if hyperkalemia, significant rise in serum creatinine, or significant fall in hematocrit or hemoglobin occurs. Pregnancy. Nursing mothers.

UROCIT-K Classification:

Urinary alkalinizer.

UROCIT-K Interactions:

Avoid concomitant potassium-sparing diuretics, anticholinergics, other drugs that slow GI motility. Monitor digoxin. May interfere with some urinary tract antibiotics. Concomitant NSAIDs, RAAS inhibitors (eg, ACEIs, ARBs, spironolactone, eplerenone, aliskiren): closely monitor potassium levels.

Adverse Reactions:

Hyperkalemia, GI upset, irritation, bleeding.

Generic Drug Availability:


How Supplied: