Pituitary disorders:
Indications for: TRIPTODUR
Central precocious puberty.
Adult Dosage:
Not applicable.
Children Dosage:
<2yrs: not established. Give as IM inj in buttock or thigh. ≥2yrs: 22.5mg once every 24 weeks. Discontinue at appropriate time point for onset of puberty. Consider switching to alternative GnRH agonist if Triptodur dose is inadequate.
TRIPTODUR Contraindications:
Pregnancy.
TRIPTODUR Warnings/Precautions:
Use aseptic technique. Must be administered by a healthcare provider. Initial transient rise in gonadotropins and sex steroids may result in increased signs/symptoms of puberty. Monitor LH and sex steroid levels at 1–2 months after treatment initiation, during, and with each subsequent dose. Measure height every 3–6 months and bone age periodically. Monitor for pseudotumor cerebri or psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Renal or hepatic impairment. Discontinue if overdosage occurs. Nursing mothers.
TRIPTODUR Classification:
GnRH agonist.
TRIPTODUR Interactions:
Concomitant hyperprolactinemic drugs: not recommended. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs). May interfere with pituitary gonadotropic and gonadal function tests.
Adverse Reactions:
Inj site reactions, menstrual bleeding, hot flush, headache, cough, infections (eg, bronchitis, gastroenteritis, influenza, nasopharyngitis, otitis externa, pharyngitis, sinusitis, upper respiratory tract infection).
Drug Elimination:
Renal, hepatic.
Generic Drug Availability:
NO
How Supplied:
Single-use kit—1
