Indications for: Trihexyphenidyl

Adjunct in Parkinsonism. Drug-induced extrapyramidal symptoms (EPS).

Adult Dosage:

Take with food. Give in 3–4 divided doses. Parkinsonism: 1mg on day 1, may increase by 2mg every 3–5 days; usual max 6–15mg/day. Concomitant levodopa: 3–6mg/day and reduce levodopa dose. EPS: 1mg on day 1; range 5–15mg/day.

Children Dosage:

Not recommended.

Trihexyphenidyl Contraindications:

Tardive dyskinesia. Narrow-angle glaucoma.

Trihexyphenidyl Warnings/Precautions:

Cardiovascular, renal, or hepatic disorders. Hypertension. Psychosis. GI or GU obstruction. Exposure to extreme heat. Monitor intraocular pressure. Avoid abrupt cessation. Nursing mothers.

Trihexyphenidyl Classification:


Trihexyphenidyl Interactions:

Potentiates CNS depression with alcohol, CNS depressants. Antagonizes psychotropics. Additive anticholinergic effects with MAOIs. Paralytic ileus with phenothiazines, tricyclic antidepressants.

Adverse Reactions:

Anticholinergic and antihistaminic effects, confusion, anhidrosis, excitement, nausea, vomiting, angle-closure glaucoma, hallucinations, neuroleptic malignant syndrome, heat stroke, drowsiness.


Formerly known under the brand name Artane.

How Supplied:

Contact supplier.