Tuberculosis:
Indications for: TRECATOR
Adjunct in tuberculosis, when INH and rifampin are not appropriate.
Adult Dosage:
Give with meals to minimize GI upset. Initially 250mg/day in 1–4 divided doses; titrate to highest tolerated dose (see full labeling). Usual range: 15–20mg/kg daily; max 1g/day.
Children Dosage:
Give with meals to minimize GI upset. 10–20mg/kg in 2–3 divided doses, or 15mg/kg once daily.
TRECATOR Contraindications:
Severe hepatic impairment.
TRECATOR Warnings/Precautions:
Confirm presence of susceptible bacterial infection before initiating therapy. Re-titrate when switching from Trecator SC sugar-coated tabs. Give with pyridoxine. Discontinue if severe cutaneous adverse reactions develop; treat appropriately. Diabetes. Do baseline and periodic blood glucose levels, eye exams (including ophthalmoscopy). Monitor thyroid function. Obtain SGOT and SGPT before and monthly; suspend if levels increase. Pregnancy: not recommended. Nursing mothers.
TRECATOR Interactions:
Avoid alcohol. Potentiates other antituberculars. Convulsions with cycloserine.
Adverse Reactions:
GI upset, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia, liver dysfunction, psychosis, drowsiness, dizziness, restlessness, headache, postural hypotension, hypoglycemia, gynecomastia, impotence, acne; rarely; peripheral/optic neuritis, visual disturbances, pellagra, thrombocytopenia, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP).
Note:
Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet which may result in higher peak levels.
Drug Elimination:
Mean (SD) Half-life: 1.92 (0.27) hours.
Generic Drug Availability:
NO
How Supplied:
Tabs—100
