Indications for: TRECATOR

Adjunct in tuberculosis, when INH and rifampin are not appropriate.

Adult Dosage:

Give with meals to minimize GI upset. Initially 250mg/day in 1–4 divided doses; titrate to highest tolerated dose (see full labeling). Usual range: 15–20mg/kg daily; max 1g/day.

Children Dosage:

Give with meals to minimize GI upset. 10–20mg/kg in 2–3 divided doses, or 15mg/kg once daily.

TRECATOR Contraindications:

Severe hepatic impairment.

TRECATOR Warnings/Precautions:

Confirm presence of susceptible bacterial infection before initiating therapy. Re-titrate when switching from Trecator SC sugar-coated tabs. Give with pyridoxine. Discontinue if severe cutaneous adverse reactions develop; treat appropriately. Diabetes. Do baseline and periodic blood glucose levels, eye exams (including ophthalmoscopy). Monitor thyroid function. Obtain SGOT and SGPT before and monthly; suspend if levels increase. Pregnancy: not recommended. Nursing mothers.

TRECATOR Interactions:

Avoid alcohol. Potentiates other antituberculars. Convulsions with cycloserine.

Adverse Reactions:

GI upset, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia, liver dysfunction, psychosis, drowsiness, dizziness, restlessness, headache, postural hypotension, hypoglycemia, gynecomastia, impotence, acne; rarely; peripheral/optic neuritis, visual disturbances, pellagra, thrombocytopenia, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP).


Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet which may result in higher peak levels.



Drug Elimination:

Mean (SD) Half-life: 1.92 (0.27) hours.

Generic Drug Availability:


How Supplied: