Select therapeutic use:

Edema:

Indications for: Torsemide

Edema.

Adult Dosage:

Edema due to CHF: 10–20mg once daily, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to renal disease: 20mg once daily, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to hepatic disease: 5–10mg once daily, give with aldosterone antagonist or potassium-sparing diuretic, may titrate upwards by doubling dose until desired response is achieved; max 40mg daily.

Children Dosage:

Not established.

Torsemide Contraindications:

Anuria. Hepatic coma. Sulfonamide or povidone allergy.

Torsemide Warnings/Precautions:

Hepatic disease with cirrhosis and ascites. New or worsening hepatic encephalopathy; consider suspending or discontinuing therapy. Renal impairment. Monitor electrolytes, blood glucose, renal function, and fluids. Pregnancy. Nursing mothers.

Torsemide Classification:

Diuretic (loop).

Torsemide Interactions:

Lithium or salicylate toxicity. Caution with NSAIDs. Antagonized by organic anion drugs (eg, probenecid) or indomethacin. Give oral dose 1hr before or 4–6hrs after cholestyramine. Ototoxicity with aminoglycosides (avoid) or ethacrynic acid. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. May affect sensitive CYP2C9 substrates or substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Risk of hypotension and/or renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs). Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids or ACTH.

Adverse Reactions:

Excessive urination; hypotension, renal dysfunction, electrolyte abnormalities, hyperglycemia, hyperuricemia, ototoxicity.

Note:

Formerly known under the brand name Demadex.

How Supplied:

Contact supplier.

Pricing for Torsemide

20mg tablet (Qty: 30)
Appx. price $11
GoodRx

Hypertension:

Indications for: Torsemide

Hypertension.

Adult Dosage:

Initially 5mg once daily; may increase to 10mg daily after 4–6 weeks.

Children Dosage:

Not established.

Torsemide Contraindications:

Anuria. Hepatic coma. Sulfonamide or povidone allergy.

Torsemide Warnings/Precautions:

Hepatic disease with cirrhosis and ascites. New or worsening hepatic encephalopathy; consider suspending or discontinuing therapy. Renal impairment. Monitor electrolytes, blood glucose, renal function, and fluids. Pregnancy. Nursing mothers.

Torsemide Classification:

Diuretic (loop).

Torsemide Interactions:

Lithium or salicylate toxicity. Caution with NSAIDs. Antagonized by organic anion drugs (eg, probenecid) or indomethacin. Give oral dose 1hr before or 4–6hrs after cholestyramine. Ototoxicity with aminoglycosides (avoid) or ethacrynic acid. Potentiated by concomitant CYP2C9 inhibitors (eg, amiodarone, fluconazole, miconazole, oxandrolone); monitor and adjust dose if needed. Antagonized by concomitant CYP2C9 inducers (eg, rifampin); monitor and adjust dose if needed. May affect sensitive CYP2C9 substrates or substrates with narrow therapeutic range (eg, celecoxib, warfarin, phenytoin); monitor and adjust dose if needed. Risk of hypotension and/or renal impairment with concomitant ACE inhibitors, ARBs, or nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs). Increased nephrotoxicity with concomitant radiocontrast agents. Increased risk of hypokalemia with concomitant corticosteroids or ACTH.

Adverse Reactions:

Excessive urination; hypotension, renal dysfunction, electrolyte abnormalities, hyperglycemia, hyperuricemia, ototoxicity.

Note:

Formerly known under the brand name Demadex.

How Supplied:

Contact supplier.

Pricing for Torsemide

20mg tablet (Qty: 30)
Appx. price $11
GoodRx