Arthritis/rheumatic disorders:
Indications for: Tolmetin 400mg
Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Treatment of acute flares and the long-term management of the chronic disease. Treatment of juvenile rheumatoid arthritis.
Adult Dosage:
Initially 400mg 3 times daily. Maintenance: 600–1800mg daily in divided doses; max 1800mg/day.
Children Dosage:
<2yrs: not recommended. ≥2yrs: Initially 20mg/kg/day in divided doses (3–4 times daily). Maintenance: usual dose range: 15–30mg/kg/day; max 30mg/kg/day.
Tolmetin 400mg Contraindications:
Aspirin allergy. Coronary artery bypass graft surgery.
Tolmetin 400mg Warnings/Precautions:
Advanced renal disease: not recommended. Hypertension; monitor. CHF. Edema. Asthma. History of ulcer disease or GI bleeding. Bleeding disorders. Dehydration. Monitor blood, hepatic, and renal function in chronic use. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. C: <30 weeks gestation; Cat. D: ≥30 weeks gestation: avoid). Nursing mothers: not recommended.
See Also:
Tolmetin 400mg Classification:
NSAID.
Tolmetin 400mg Interactions:
Avoid aspirin. May antagonize ACE inhibitors, diuretics. Increased risk of GI bleed with oral corticosteroids, anticoagulants (monitor), alcohol, smoking. Methotrexate excretion reduced. Increases lithium levels.
Adverse Reactions:
GI upset, abdominal pain, dyspepsia, flatulence, headache, asthenia, elevated BP, edema, dizziness, weight gain, weight loss; rash (discontinue if occurs), GI ulcer/bleed, elevated liver enzymes (discontinue if hepatotoxicity develops), blood dyscrasias, renal papillary necrosis. See literature re: risk of cardiovascular events.
Note:
Formerly known under the brand name Tolectin DS.
How Supplied:
Contact supplier.
