Protozoal infections:
Indications for: TINDAMAX
Giardiasis. Intestinal amebiasis. Amebic liver abscess.
Adult Dosage:
Take with food. Giardiasis: 2g as a single dose. Intestinal amebiasis: 2g once daily for 3 days. Amebic liver abscess: 2g once daily for 3–5 days. Hemodialysis: if dose given on or prior to a dialysis day, supplement with ½ the recommended dose after session.
Children Dosage:
<3yrs: not established. Take with food. ≥3yrs: Giardiasis: 50mg/kg (max 2g) as a single dose. Intestinal amebiasis: 50mg/kg/day (max 2g) for 3 days. Amebic liver abscess: 50mg/kg/day (max 2g) for 3–5 days.
TINDAMAX Contraindications:
Previous hypersensitivity to other nitroimidazole derivatives. Cockayne syndrome.
Boxed Warning:
Potential risk for carcinogenicity.
TINDAMAX Warnings/Precautions:
Potential risk for genotoxicity and carcinogenicity; avoid chronic use. Discontinue if neurological effects occur. Vaginal candidiasis. Blood dyscrasias. Monitor leukocytes if re-treatment needed. Hepatic dysfunction. Elderly. Pregnancy. Nursing mothers: not recommended (during and for 72hrs after last dose).
TINDAMAX Classification:
Nitroimidazole.
TINDAMAX Interactions:
Avoid alcohol during and for 3 days after therapy. Do not give within 2 weeks of disulfiram. May potentiate oral anticoagulants, lithium, phenytoin. Monitor cyclosporine, tacrolimus, fluorouracil. May be antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). May be potentiated by CYP3A4 inhibitors (eg, cimetidine, ketoconazole). Separate dosing of cholestyramine. May interfere with serum chemistry tests (eg, AST, ALT, LDH, triglycerides, hexokinase glucose).
Adverse Reactions:
Metallic/bitter taste, nausea, weakness/fatigue/malaise, dyspepsia/cramps/epigastric discomfort, vomiting, anorexia, constipation, dizziness, headache, transient leukopenia/neutropenia; seizures, peripheral neuropathy.
Generic Drug Availability:
YES
How Supplied:
Tabs—20
Vaginal infections:
Indications for: TINDAMAX
Trichomoniasis. Bacterial vaginosis in non-pregnant women.
Adult Dosage:
Take with food. Trichomoniasis: 2g as a single dose; treat consorts also. Bacterial vaginosis: 2g once daily for 2 days or 1g once daily for 5 days. Hemodialysis: if dose given on or prior to a dialysis day, supplement with ½ the recommended dose after session.
Children Dosage:
Not established.
TINDAMAX Contraindications:
Previous hypersensitivity to other nitroimidazole derivatives. Cockayne syndrome.
Boxed Warning:
Potential risk for carcinogenicity.
TINDAMAX Warnings/Precautions:
Potential risk for genotoxicity and carcinogenicity; avoid chronic use. Discontinue if neurological effects occur. Vaginal candidiasis. Blood dyscrasias. Monitor leukocytes if re-treatment needed. Hepatic dysfunction. Elderly. Pregnancy. Nursing mothers: not recommended (during and for 72hrs after last dose).
TINDAMAX Classification:
Nitroimidazole.
TINDAMAX Interactions:
Avoid alcohol during and for 3 days after therapy. Do not give within 2 weeks of disulfiram. May potentiate oral anticoagulants, lithium, phenytoin. Monitor cyclosporine, tacrolimus, fluorouracil. May be antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). May be potentiated by CYP3A4 inhibitors (eg, cimetidine, ketoconazole). Separate dosing of cholestyramine. May interfere with serum chemistry tests (eg, AST, ALT, LDH, triglycerides, hexokinase glucose).
Adverse Reactions:
Metallic/bitter taste, nausea, weakness/fatigue/malaise, dyspepsia/cramps/epigastric discomfort, vomiting, anorexia, constipation, dizziness, headache, transient leukopenia/neutropenia; seizures, peripheral neuropathy.
Generic Drug Availability:
YES
How Supplied:
Tabs—20
