Miscellaneous urogenital disorders:
Indications for: THIOLA
In combination with high fluid intake, alkali and diet modification, to prevent cystine stone formation in patients with severe homozygous cystinuria who are not responsive to these measures alone.
Adult Dosage:
Give in 3 divided doses at least 1hr before or 2hrs after meals. EC tabs: swallow whole; if difficulty swallowing, it can be crushed and mixed with applesauce. Initially 800mg/day; usual dose 1000mg/day. Measure urinary cystine at 1 month after initiation, and every 3 months thereafter. Adjust dose to maintain urinary cystine levels <250mg/L. Severe toxicity to d-penicillamine: may start with lower dose.
Children Dosage:
<20kg: not established. ≥20kg: Give in 3 divided doses at least 1hr before or 2hrs after meals. EC tabs: swallow whole; if difficulty swallowing, it can be crushed and mixed with applesauce. Initially 15mg/kg/day. Avoid doses >50mg/kg per day (increased risk of proteinuria). Measure urinary cystine at 1 month after initiation, and every 3 months thereafter. Adjust dose to maintain urinary cystine levels <250mg/L. Severe toxicity to d-penicillamine: may start with lower dose.
THIOLA Warnings/Precautions:
Monitor urinary protein prior to initiation, then every 3 to 6 months during treatment; discontinue if proteinuria occurs. Monitor renal function. Elderly. Pregnancy. Nursing mothers: not recommended.
See Also:
THIOLA Classification:
Reducing agent.
THIOLA Interactions:
EC tabs: avoid alcohol 2hrs before and 3hrs after dose.
Adverse Reactions:
Nausea, diarrhea or soft stools, oral ulcers, rash, fatigue, fever, arthralgia, proteinuria, emesis; hypersensitivity reactions, hypogeusia.
Generic Drug Availability:
Tabs (YES); EC tabs (NO)
How Supplied:
Tabs—100; EC tabs 100mg—300; 300mg—90
