Select therapeutic use:

Acne:

Indications for: TAZORAC

Mild to moderate facial acne vulgaris (0.1% strength only).

Adult Dosage:

Cleanse and dry skin. Apply thin film of 0.1% strength to lesions on face once daily in the PM. Women of childbearing potential: begin therapy during normal menses.

Children Dosage:

<12yrs: not established.

TAZORAC Contraindications:

Pregnancy.

TAZORAC Warnings/Precautions:

Embryo-fetal toxicity. Obtain reliable negative pregnancy test within 2wks before starting therapy; use effective contraception during therapy. Do not use on broken, eczematous, or sunburned skin. Sun sensitivity. Avoid eyes, mouth, mucous membranes, sun and UV light; use adequate sun protection. Increased irritation in extreme weather. Discontinue or reduce frequency if excessive irritation occurs. Nursing mothers.

TAZORAC Classification:

Retinoid.

TAZORAC Interactions:

Avoid use until the effects of strong topical drying agents have subsided. Caution with other photosensitizers or irritants. Separate use of emollients at least 1hr before Tazorac.

Adverse Reactions:

Desquamation, burning/stinging, dry skin, erythema, pruritus, worsening of psoriasis, irritation, skin pain; photosensitivity.

Metabolism:

Hepatic. >99% serum protein bound.

Drug Elimination:

Renal, fecal. Half-life: ~18 hours.

Generic Drug Availability:

Gel (YES); Crm 0.1% (YES), 0.05% (NO)

How Supplied:

Gel—30g, 100g; Crm—30g, 60g

Psoriasis:

Indications for: TAZORAC

Plaque psoriasis.

Adult Dosage:

Cleanse and dry skin. Apply thin film to lesions once daily in the PM; for gel, apply to max 20% body surface area. Initiate with 0.05% strength; may increase to 0.1% as tolerated and clinically indicated. Women of childbearing potential: begin therapy during normal menses.

Children Dosage:

<18yrs: not established.

TAZORAC Contraindications:

Pregnancy.

TAZORAC Warnings/Precautions:

Embryo-fetal toxicity. Obtain reliable negative pregnancy test within 2wks before starting therapy; use effective contraception during therapy. Do not use on broken, eczematous, or sunburned skin. Sun sensitivity. Avoid eyes, mouth, mucous membranes, sun and UV light; use adequate sun protection. Increased irritation in extreme weather. Discontinue or reduce frequency if excessive irritation occurs. Nursing mothers.

TAZORAC Classification:

Retinoid.

TAZORAC Interactions:

Avoid use until the effects of strong topical drying agents have subsided. Caution with other photosensitizers or irritants. Separate use of emollients at least 1hr before Tazorac.

Adverse Reactions:

Desquamation, burning/stinging, dry skin, erythema, pruritus, worsening of psoriasis, irritation, skin pain; photosensitivity.

Metabolism:

Hepatic. >99% serum protein bound.

Drug Elimination:

Renal, fecal. Half-life: ~18 hours.

Generic Drug Availability:

Gel (YES); Crm 0.1% (YES), 0.05% (NO)

How Supplied:

Gel—30g, 100g; Crm—30g, 60g