Select therapeutic use:

Bacterial infections:

Indications for TALICIA:

Treatment of H. pylori infection.

Adult:

Swallow whole. Take with food. ≥18yrs: 4 caps every 8hrs for 14 days. Hepatic or severe renal (GFR <30mL/min) impairment: avoid.

Children:

<18yrs: not established.

Contraindications:

Omeprazole: concomitant rilpivirine-containing products. Rifabutin: concomitant delavirdine, voriconazole.

Warnings/Precautions:

Discontinue and treat if hypersensitivity reactions occur. Evaluate if diarrhea occurs. Discontinue if acute interstitial nephritis develops. Cutaneous and systemic lupus erythematosus. Avoid in those with mononucleosis. Uveitis: refer for an eye exam if suspected; suspend therapy if needed. Hepatic or severe renal impairment (see Adults). Pregnancy. Nursing mothers.

Pharmacologic Class:

Proton pump inhibitor + antibiotics (penicillin + rifamycin).

Interactions:

May be antagonized by other CYP2C19 or CYP3A4 inducers (eg, St. John's wort, rifampin); avoid. May antagonize hormonal contraceptives; use additional or alternative non-hormonal methods. Omeprazole antagonizes clopidogrel; consider alternative anti-platelet therapy. May be potentiated by CYP2C19 and/or CYP3A inhibitors (eg, fluconazole, itraconazole, posaconazole, clarithromycin); avoid. May potentiate CYP2C19 substrates (eg, citalopram, cilostazol, phenytoin, diazepam), high-dose methotrexate (avoid), digoxin, tacrolimus; monitor. Avoid concomitant amprenavir, indinavir, lopinavir/ritonavir, saquinavir/ritonavir, ritonavir, tipranavir/ritonavir, fosamprenavir/ritonavir, nelfinavir. Amoxicillin potentiated by probenecid. Increased incidence of skin rash with allopurinol; discontinue allopurinol if occurs. Monitor INR, PT with warfarin or other oral anticoagulants. May alter absorption of pH-dependent drugs (eg, iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole). Monitor drugs metabolized by CYP450 (eg, cyclosporine, disulfiram). May interfere with neuroendocrine diagnostic tests; discontinue Talicia 14 days prior to CgA level assessment; may need to repeat test. Amoxicillin may cause false (+) glucose test with Benedict's soln. May cause false (+) results with secretin stimulation test or urine tests for tetrahydrocannabinol.

Adverse Reactions:

Diarrhea, headache, nausea, abdominal pain, chromaturia, rash, dyspepsia, oropharyngeal pain, vomiting, vulvovaginal candidiasis; possible C.difficile-associated diarrhea.

Generic Availability:

NO

How Supplied:

Caps—84, 168

Pricing for TALICIA

10mg/250mg/12.5mg capsule (Qty: 168)
Appx. price $673
GoodRx

Hyperacidity, GERD, and ulcers:

Indications for TALICIA:

Treatment of H. pylori infection.

Adult:

Swallow whole. Take with food. ≥18yrs: 4 caps every 8hrs for 14 days. Hepatic or severe renal (GFR <30mL/min) impairment: avoid.

Children:

<18yrs: not established.

Contraindications:

Omeprazole: concomitant rilpivirine-containing products. Rifabutin: concomitant delavirdine, voriconazole.

Warnings/Precautions:

Discontinue and treat if hypersensitivity reactions occur. Evaluate if diarrhea occurs. Discontinue if acute interstitial nephritis develops. Cutaneous and systemic lupus erythematosus. Avoid in those with mononucleosis. Uveitis: refer for an eye exam if suspected; suspend therapy if needed. Hepatic or severe renal impairment (see Adults). Pregnancy. Nursing mothers.

Pharmacologic Class:

Proton pump inhibitor + antibiotics (penicillin + rifamycin).

Interactions:

May be antagonized by other CYP2C19 or CYP3A4 inducers (eg, St. John's wort, rifampin); avoid. May antagonize hormonal contraceptives; use additional or alternative non-hormonal methods. Omeprazole antagonizes clopidogrel; consider alternative anti-platelet therapy. May be potentiated by CYP2C19 and/or CYP3A inhibitors (eg, fluconazole, itraconazole, posaconazole, clarithromycin); avoid. May potentiate CYP2C19 substrates (eg, citalopram, cilostazol, phenytoin, diazepam), high-dose methotrexate (avoid), digoxin, tacrolimus; monitor. Avoid concomitant amprenavir, indinavir, lopinavir/ritonavir, saquinavir/ritonavir, ritonavir, tipranavir/ritonavir, fosamprenavir/ritonavir, nelfinavir. Amoxicillin potentiated by probenecid. Increased incidence of skin rash with allopurinol; discontinue allopurinol if occurs. Monitor INR, PT with warfarin or other oral anticoagulants. May alter absorption of pH-dependent drugs (eg, iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole). Monitor drugs metabolized by CYP450 (eg, cyclosporine, disulfiram). May interfere with neuroendocrine diagnostic tests; discontinue Talicia 14 days prior to CgA level assessment; may need to repeat test. Amoxicillin may cause false (+) glucose test with Benedict's soln. May cause false (+) results with secretin stimulation test or urine tests for tetrahydrocannabinol.

Adverse Reactions:

Diarrhea, headache, nausea, abdominal pain, chromaturia, rash, dyspepsia, oropharyngeal pain, vomiting, vulvovaginal candidiasis; possible C.difficile-associated diarrhea.

Generic Availability:

NO

How Supplied:

Caps—84, 168

Pricing for TALICIA

10mg/250mg/12.5mg capsule (Qty: 168)
Appx. price $673
GoodRx