Pituitary disorders:

Indications for SUPPRELIN LA:

Treatment of central precocious puberty.


Not applicable.


<2yrs: not recommended. ≥2yrs: Insert 1 implant SC in the inner aspect of the upper arm. Remove after 12 months; may replace. Consider discontinuing at appropriate time point for onset of puberty.




Use aseptic technique. Monitor for psychiatric symptoms. History of seizures/epilepsy, cerebrovascular disorders, CNS anomalies or tumors: risk of convulsions. Monitor LH, FSH, and estradiol or testosterone at 1 month post implantation, then every 6 months thereafter. Assess height and bone age every 6–12 months. Nursing mothers.

Pharmacologic Class:

GnRH agonist.


May interfere with pituitary gonadotropic and gonadal function tests. Caution with concomitant drugs that are associated with convulsions (eg, bupropion, SSRIs).

Adverse Reactions:

Implant site reactions (eg, discomfort, bruising, pain, soreness, erythema, swelling), initial worsening of signs/symptoms.

How Supplied:

Kit—1 (w. implant and insertion tool)

Pricing for SUPPRELIN LA

50mg implant (Qty: 1)
Appx. price $40866