Hereditary angioedema:
Indications for: RUCONEST
Treatment of acute attacks in adult and adolescent patients with hereditary angioedema (HAE).
Limitations of Use:
Efficacy not established in HAE patients with laryngeal attacks.
Adult Dosage:
Give by slow IV inj over 5 mins. <84kg: 50 IU/kg. ≥84kg: 4200 IU. Max 4200 IU/dose. May give second dose if attack symptoms persist; max 2 doses/24hrs.
Children Dosage:
Not established.
RUCONEST Contraindications:
Allergy to rabbits or rabbit-derived products.
RUCONEST Warnings/Precautions:
Discontinue if hypersensitivity reactions occur. Monitor patients with known risk factors for thrombotic events (eg, indwelling venous catheter, history of thrombosis, atherosclerosis, morbid obesity, immobility). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
RUCONEST Classification:
C1 inhibitor.
RUCONEST Interactions:
Risk of thrombotic events with concomitant oral contraceptives or certain androgens.
Adverse Reactions:
Headache, nausea, diarrhea; thrombotic events, hypersensitivity reactions (may be severe).
Generic Drug Availability:
NO
How Supplied:
Single-use vial—1
